Gastroenterology

Effect of Ethanolic Extract of Coconut (Cocos nucifera) on Aspirin-induced Gastric Ulcer in Albino Rats

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Andre Robert introduced the term ‘cytoprotection’ first time. He used this term for protection of experimentally induced gastric ulcer by prostaglandins. But later on, this term is broadly used for protection of gastric mucosal injury except injuries caused by gastric acid inhibition or neutralization.

Desquamation prevalence in stomach ulcer
Desquamation prevalence in stomach ulcer

Despite intensive research of the last few decades, gastro-protection is incompletely understood, and we are still far away from effectively treating Helicobacter pylori -negative ulcers and preventing non-steroidal anti-inflammatory drugs-caused erosions and ulcers in the upper and lower gastrointestinal tract; hence “gastric cytoprotection” research is still relevant. Aspirin, also known as acetylsalicylic acid, is commonly used as an analgesic, antiinflammatory, antipyretic, antiplatelet and antithrombotic drug. Read More>>>>>>>

Pneumatosis Intestinalis in Patient with Relapsing Polychondritis

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Relapsing polychondritis (RP) involves recurrently and progressively proteoglycan-rich organs and was first described in 1923 as “Polychondropathia. Yun et al. reported first RP case in Korea. Meanwhile, pneumatosis intestinalis (PI) refers to the presence of gas within the submucosa or subserosa of the bowel well.

Chest plain radiography
Chest plain radiography

In 2007, a RP patient who presented PI was reported in Korea for the first time in the world. We have then experienced a second PI case in a patient with RP. We suspected an association between RP, the episode of PI, and possibly steroid use as well. We examined the case of pneumatosis intestinalis in a 44-year-old male of RP patient. Read More>>>>>>>

Capsule Endoscopy for Differentiating Early Crohn’s Disease from Behçet’s Disease

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Crohn’s disease (CD) and Behçet’s disease (BD) are two major causes of inflammatory lesions in the small bowel. For detecting such lesions, the most sensitive exam is small-bowel capsule endoscopy (CE), an imaging modality suitable for evaluating lesions of the small intestine, with a relatively low rate of capsule retention.

Behçet's Disease
Behçet’s Disease

However, few reports have employed CE to compare the small-bowel inflammation in early CD with that in early BD. Thus, the aim of our study was to obtain a systematic characterization of small-bowel lesions in early CD and BD by using CE. Methods: This retrospective single-center study included 22 patients with early CD and 16 patients with early BD. The patients underwent small-bowel CE for detection and characterization of small-bowel lesions. Read More>>>>>

Interest of Corticosteroid Injection in Refractory Benign Stenosis of the Esophagus

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The post-surgical anastomotic oesophageal stenosis are usually benign, requiring one to three dilation sessions to achieve a longlasting functional result,but sometimes these stenosis can recur rapidly after 5 sessions of endoscopic dilation (refractory stenosis). The purpose of this work is to show, through an observation, the interest of the injection of the corticosteroids during the endoscopic treatment of refractory oesophageal stenosis.

Installation of guide rod before dilation.
Installation of guide rod before dilation.

Case Report : Patient, 60 years old, with no pathological history, admitted to the emergency room of the Military Hospital of Rabat for the management of a upper gastrointestinal bleeding (hematemesis) after accidental ingestion of 150 ml hydrochloric acid (the spirit of salt). Read More>>>>>>>>>>>>>

Multiple Beneficial effects Associated with Coffee Consumption on Human Liver

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Liver is considered to be an important organ of the human body. It is second largest organ of the body after skin. It mainly performs the functions of digestion, metabolism, and storage of nutrients.

Coffee Consumption
Coffee Consumption

Liver is located at upper right quadrant of human body. Nutrients have to pass through liver after absorption into blood stream. Liver metabolizes amino acids derived from food sources. Liver performs urea production as well as alcohol metabolism. Liver detoxifies chemicals, toxins and drugs after administration. Ultimately liver nullifies effect of various toxins.  Read More>>>>>>>>

Cocaine-induced Fulminant Hepatitis

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A 28-year-old man was admitted to our hospital on November 14, 2016 because of psychomotor agitation with fear delusions after ingesting 0.5 g of cocaine. He had no medical history of interest.

Fulminant Hepatitis

As a toxic consumption history, he referred being an excigarette smoker of a pack a day, referred an ex-consumption of 10-12 alcohol units per day, and an ex-consumption of cannabis. Cocaine consumption started at 16 years old but at that time it had become sporadic. On examination in the emergency department, the patient presented a Glasgow Coma Score (GCS) of 12 with bilateral mydriasis, skin and mucous dryness, tachycardia and self- limiting temperature peak of 39.5°C.  Read More>>>>>>>>>

Why Don’t Immune Checkpoint Inhibitors Work in Colorectal Cancer?

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Immunotherapy, working through immune checkpoint blockade has achieved notable responses in multiple tumor types including malignant melanoma, renal cell carcinoma, non-small cell lung cancer, bladder carcinoma, Hodgkin’s lymphoma, triple-negative breast carcinoma as well as head and neck cancer.

Proteins involved in the immune interaction
Proteins involved in the immune interaction

However, CRC appears to be one of the tumor types that shows a poor response to immune checkpoint inhibitors, apart from the MSI CRC subtype which accounts for about 5% of advanced and metastatic CRC. Read More>>>>>>>>