Gastric cancer, a multifactorial disease is one of the leading causes of death worldwide. Among all other cancers it ranks in number four because of its occurrence. Several factors are involved behind this deadly disease.
The factors could be environmental, bacterial or it could be host related. Some of the ethnic groups are more prone to this disease in comparison with others. Factors that could be responsible for gastric cancer occurrence. Though the number of gastric cancer incidents are getting low in the Western countries, which has been observed from the past few years, but still it remains pretty high in Asian region i.e. Korea, Japan. Read More>>>>>>>
Although alcoholic hepatitis (AH) is a relatively common life threatening liver disease, some controversy exists about its assessment. The most important two points are to assess the mortality risk and the decision to use corticosteroid and/or pentoxyfylline treatment. Several prognostic scores have been described regarding these two key factors.
The first score for AH, the discriminant function (DF) score, was described in 1978 and modified in 1989. The second score, the Glasgow AH (GAHS) score, was developed in 2005 and revealed that patients with GAHS ≥ 9 may benefit from treatment with corticosteroids. Thereafter, the Model for End-Stage Liver Disease (MELD) and age, bilirubin, International Normalized Ratio (INR) and creatinine (ABIC) scores have been presented to assess patients diagnosed with AH. Read More>>>>>>>>
Metformin is the most used anti-hyperglycemic agent for the treatment of Type 2 Diabetes Mellitus. It is considered a very good drug, with low risk and high benefit, if prescribed in the right clinical condition.
It allows a good control of diabetes and lowers blood triglycerides of 15% to 20%, without any weight gain and without impairing the glucose level. These effects are the result of inhibition of hepatic gluconeogenesis and fatty acid oxidation, improving peripheral glucose sensitivity, reducing intestinal absorption and appetite too. Acute side effects are reported in about 20% of patients: nausea, abdominal discomfort, metals flavor, anorexia. Read More>>>>>>
Effect of Ethanolic Extract of Coconut (Cocos nucifera) on Aspirin-induced Gastric Ulcer in Albino Rats
Andre Robert introduced the term ‘cytoprotection’ first time. He used this term for protection of experimentally induced gastric ulcer by prostaglandins. But later on, this term is broadly used for protection of gastric mucosal injury except injuries caused by gastric acid inhibition or neutralization.
Despite intensive research of the last few decades, gastro-protection is incompletely understood, and we are still far away from effectively treating Helicobacter pylori -negative ulcers and preventing non-steroidal anti-inflammatory drugs-caused erosions and ulcers in the upper and lower gastrointestinal tract; hence “gastric cytoprotection” research is still relevant. Aspirin, also known as acetylsalicylic acid, is commonly used as an analgesic, antiinflammatory, antipyretic, antiplatelet and antithrombotic drug. Read More>>>>>>>
Relapsing polychondritis (RP) involves recurrently and progressively proteoglycan-rich organs and was first described in 1923 as “Polychondropathia. Yun et al. reported first RP case in Korea. Meanwhile, pneumatosis intestinalis (PI) refers to the presence of gas within the submucosa or subserosa of the bowel well.
In 2007, a RP patient who presented PI was reported in Korea for the first time in the world. We have then experienced a second PI case in a patient with RP. We suspected an association between RP, the episode of PI, and possibly steroid use as well. We examined the case of pneumatosis intestinalis in a 44-year-old male of RP patient. Read More>>>>>>>
Crohn’s disease (CD) and Behçet’s disease (BD) are two major causes of inflammatory lesions in the small bowel. For detecting such lesions, the most sensitive exam is small-bowel capsule endoscopy (CE), an imaging modality suitable for evaluating lesions of the small intestine, with a relatively low rate of capsule retention.
However, few reports have employed CE to compare the small-bowel inflammation in early CD with that in early BD. Thus, the aim of our study was to obtain a systematic characterization of small-bowel lesions in early CD and BD by using CE. Methods: This retrospective single-center study included 22 patients with early CD and 16 patients with early BD. The patients underwent small-bowel CE for detection and characterization of small-bowel lesions. Read More>>>>>