Pathology

Invasive Micro Papillary Carcinoma of the Sigmoid Colon: Distinct Entity

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Invasive micro papillary carcinoma (IMPC) has been recently recognized by WHO as a rare distinctive and aggressive variant of adenocarcinoma. With high incidence of lymph node and distant metastasis, it was first described in breast, but recently been reported in other organs such as lungs, urinary bladder, ovaries or salivary glands. It carries worse Prognosis than conventional colorectal carcinoma.

AB view show free air under diaphragm
AB view show free air under diaphragm

Pathologically it is characterized by mall clusters of malignant cells with abundant eosinophilic cytoplasm and pleomorphic nuclei, micropapillae inhabit lacunar-like spaces and demonstrate a “reverse polarity” configuration, with apical surfaces facing the periphery rather than the center.  Read More>>>>>>>>>

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Fine Needle Aspiration Cytology in Warthin’s Tumor: A Diagnostic tool

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About 80% of parotid tumors are benign neoplasms. Warthin’s tumor is the second most common benign neoplasm of the salivary glands after pleomorphic adenoma, accounting for 5% to 6% of all salivary gland tumors. It is located almost exclusively in the parotid gland and may occur bilaterally or as multiple lesions.

Bilateral painless swelling in the parotid region
Bilateral painless swelling in the parotid region

Fine-needle aspiration cytology (FNAC) is frequently used to investigate salivary gland lesions preoperatively. It is a rapid, easy to perform, noninvasive, and has minimal complications. The overall accuracy of FNAC in predicting whether a salivary gland mass is benign or malignant ranges from 80% to 100%. Read More>>>>>>

Consented Autopsy-Never-Failing yet Ever Falling

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Autopsy, derived from the Greek ‘autos’ and ‘opsomeri’ means ‘to see for oneself, and originates from mummification using human dissection around 3000BC. Over five millennia it has enabled the study of human anatomy, physiology, and pathophysiology culminating in 21st century medicine.

Consented Autopsy
Consented Autopsy

After such a rich and rewarding history, autopsy is on the brink of extinction. During the 1980s, around 30% of adult inpatient deaths in the United Kingdom were followed with consented autopsy, yet by 2013 this figure had fallen to less than 1% . The severity of this decline has led to the extinction of consented autopsy in 25% of hospitals in the UK. Marked declines have been noted around the globe. Read More>>>>>>>>

A Granulomatous Hypophysitis “Consequent” to a Silent ACTH Cell Adenoma

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Pituitary inflammatory lesions are uncommon: a granulomatous inflammatory reaction can be caused by systemic tuberculosis, syphilis or fungal infections, being usually an incidental autopsy finding.

Periphery of the adenoma
Periphery of the adenoma

They come to the pathologist more frequently when they are at an advanced stage, producing a mass effect and/or hypothalamic. However, the most enigmatic form of granulomatous hypophysitis is idiopathic. Exceptional is the association of this inflammatory lesion with adenomatous neoplastic one. The aim of our report was to make assumptions on the pathogenesis of this unlikely association. Read More>>>>>>

Post Monitor Studies for the Treatment of Speech Hand Synchronization for Adult who Stutter: 3 Months Follow Up

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The aim of the above study was to follow up for 3 months of stuttering therapy procedure in adults who stutters accomplishing spontaneous fluent speech. In this pilot study, 30 subjects were selected and divided into (i) speech-hand synchronization (SHS) (ii) Camperdown Programme (CP) and (iii) control group (CG) for the treatment therapy.

Speech Hand Synchronization
Speech Hand Synchronization

The post-treatment sessions were carried out for 3 months for 50 minutes a day for 10 weeks and each week was considered as week days (5 days). The SHS and CP patients could not show the significant association in post-treatment sessions for 3 months’ sessions. SSI-4, OASES and LCB were seems to be non-significant. However, SHS and CP was also seeming to be positive effect in assessments measuring well-being. Read More>>>>>>>

Metastatic Salivary Duct Carcinoma of the Submandibular Gland Presenting as a Poorly Differentiated Carcinoma of Unknown Primary

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In this research note, Rosemarie Di Donato and his team describe Salivary duct carcinoma is an aggressive malignancy that most commonly arises in the parotid gland.

Metastatic Salivary Duct Carcinoma
Metastatic Salivary Duct Carcinoma

Few case reports describe this entity occurring in the submandibular gland. This entity can metastasize locally early and therefore is an important differential diagnosis of metastatic disease in cervical lymph nodes. Read More>>>>>>>

The Case for PAP-HPV Co-testing: A Conservative Approach is Warranted and More

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The Pap test has been the most successful screening method for the prevention of cervical cancer with a seventy per cent decrease in its death rate since 1950. This is in the face of the sexual revolution of the 1960’s occasioned in part by the introduction of the birth control pill in 1960.

PAP-HPV Co-testing
PAP-HPV Co-testing

The subsequent change in sexual mores and increased promiscuity should have resulted in an increased incidence and death rate from cervical cancer. In fact the detection of cervical intraepithelial neoplasia (CIN) increased dramatically and its subdequent treatment resulted in successful cancer prevention. Read More>>>>