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EAM as a New Conditioning Regimen for Lymphoma Patients Undergoing Autologous Progenitor Cell Transplantation
Autologous progenitor cells transplantation (APCT) after a high dose conditioning chemotherapy is now an established treatment modality for many hematological malignancies such as lymphoma.
Clinical results and survival after APCT depend on disease chemo sensitivity at transplant and the efficacy of the conditioning regimen at eradicating the residual tumor cell clone. The impact of the conditioning regimen is a controversial matter and despite efforts to identify high-dose regimens with increasing antitumor activity and acceptable toxicity to normal tissues, there is not yet clear evidence of a superior conditioning platform that should be applied in the setting of recurring lymphoma patients, at least in terms of tumor-eradicating capacity. Read More>>>
Bentonite is clay material. Clays are naturally occurring, and they are the most abundant surface minerals on earth, constituting approximately 40% of earth’s crust. They were formed in various ways such as, weathering product of volcanic ash, tuff or other rocks, a hydrothermal product, and as a diagenetic product in ocean basins.
Bentonites have a multitude of applications because of their surface activity. Applications include among others, ceramics, paper industry, building materials. Lagaly and Ziesmer distinguish between large volume applications, which include, foundry moulding sands, oil well drilling, pelletizing iron ore, sealing materials and civil engineering applications, and small volume applications which include paints, adhesives (in asphaltic materials and latex), for pharmaceutical uses, in cosmetics, as filling materials and for water (and wine) purification. Read More>>>>>>
Kaldor proposed a ordinary differential system to model business cycle, in which the gross investment depends on the level of output and capital stock. Thereafter, this model was often discussed, see and references there in. The Kalecki business model was a few years earlier than the Kaldor one.
Kalecki assumed that the saved part of profit is invested and the capital growth is due to past investment decisions. There is a gestation period or a time lag, after which capital equipment is available for production. In 1999, Krawiec and Szydlowski have formulated the Kaldor-Kalecki business cycle model based on the multiplier dynamics which is the core of both the Kaldor (after Keynes) and Kalecki approach. Read More>>>>>>>>>>
Although alcoholic hepatitis (AH) is a relatively common life threatening liver disease, some controversy exists about its assessment. The most important two points are to assess the mortality risk and the decision to use corticosteroid and/or pentoxyfylline treatment. Several prognostic scores have been described regarding these two key factors.
The first score for AH, the discriminant function (DF) score, was described in 1978 and modified in 1989. The second score, the Glasgow AH (GAHS) score, was developed in 2005 and revealed that patients with GAHS ≥ 9 may benefit from treatment with corticosteroids. Thereafter, the Model for End-Stage Liver Disease (MELD) and age, bilirubin, International Normalized Ratio (INR) and creatinine (ABIC) scores have been presented to assess patients diagnosed with AH. Read More>>>>>>>>
Multiple scientific works are devoted to elaboration of methods for making nanostructured substances as well as for investigating a behavior of synthesized samples at different conditions. The study of formation, growth and behavior of nanostructures is a constituent part of mesophysics as the science dealing with the substance, revealing classical and quantum features simultaneously in the field of spatial scale 10–9–10–7 m.
Quantum features of a substance are most conspicuous with the availability of strong bonds between atoms. We consider two types of objects: 1) crystals whose lattice is formed by atoms of the same type oscillating as harmonic oscillators with typical frequencies ~1012–1014 s–1 (“atomic crystals”), and 2) crystals generated by macromolecules exhibiting both oscillating nature of internal motions with the given frequencies and rotary isomerism with the frequencies ~1010–1011 s–1 (“molecular crystals”). Read More>>>>>>>>>>
Madindoline A Affects the Osteogenic Potential and the Wnt Signaling Pathways during Osteogenic Differentiation of Human Mesenchymal Stem Cells in vitro
Mesenchymal stem cells (MSCs) differentiate to mature osteoblasts during a process named osteogenesis, which is characterized by upregulated alkaline phosphatase (ALP) activity and formation of a calcium-rich mineralized extracellular matrix (ECM).
Several signaling pathways are involved in regulation of osteogenesis and direct MSCs into the osteogenic lineage, where the runt-related transcription factor 2 (RUNX2) is the master switch for osteogenesis . Also the Wnt signaling pathways are essential for the guidance of MSCs towards the osteoblastic lineage. The canonical Wnt signaling pathway is implicated as the dominant mechanism in bone biology. Read More>>>>>