journal of il-6 inhibitor

Madindoline A Affects the Osteogenic Potential and the Wnt Signaling Pathways during Osteogenic Differentiation of Human Mesenchymal Stem Cells in vitro

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Mesenchymal stem cells (MSCs) differentiate to mature osteoblasts during a process named osteogenesis, which is characterized by upregulated alkaline phosphatase (ALP) activity and formation of a calcium-rich mineralized extracellular matrix (ECM).

Madindoline A
Madindoline A

Several signaling pathways are involved in regulation of osteogenesis and direct MSCs into the osteogenic lineage, where the runt-related transcription factor 2 (RUNX2) is the master switch for osteogenesis . Also the Wnt signaling pathways are essential for the guidance of MSCs towards the osteoblastic lineage. The canonical Wnt signaling pathway is implicated as the dominant mechanism in bone biology.  Read More>>>>>