Synthesis of Cryptosanguinolentine and Its Phenyl Derivative via Eco-Friendly Sources
Cryptolepis sanquinolenta, a shrub indigenous to tropical West Africa, has been widely used by traditional healers for the treatment of various ailments. Crude concoctions made from various parts of the plant are used against certain bacteria, malaria and in the clinical therapy for rheumatism and urinary tract infections.
This wide spectrum of biological uses encouraged researchers to isolate biologically active components eventually identified as the indoloquinoline alkaloids cryptotackiene, cryptolepine and cryptosanguinolentine. These indoloquinoline alkaloids and their methyl derivatives possess a suitable structural framework for DNA intercalation; the planar aromatic nature can easily intercalate with the DNA double helix resulting in dramatic changes in DNA conformation and hence inhibiting DNA replication, transcription, and/or topoisomerase activities. Read more>>>>>>>>>>>
OMICS Journals 